다발성 치아우식증 소아에서 타액 단백질의 특성
charateristics of the salivary proteins in the children with rampant dental caries
양호정, 장희순, 지용실, 김조자,
소속 상세정보
양호정 ( ) - 연세대학교
장희순 ( ) - 연세대학교
지용실 ( ) - 연세대학교
김조자 ( ) - 연세대학교
KMID : 0358919960230020415
Abstract
As a part of host factors of dental caries, saliva has been well known for its impotant role in relation to dental caries. The studies on its physical and chemical characteristics on development and progress of dental caries has been conducted.
Recently, various comparisons between saliva of caries-susceptable individuals and caries-free individuals has been done and the efforts to understand the mechanisms of salivary intervention of development and progress of dental caries is
actively
in
progress. In this study, 15 children with rampant dental caries and 15 caries free children without any systemic diseases from the ages of 2 to 5 were chosen for the experiment and the whole saliva and parotid saliva from each individuals were
collected
and protein compositions were compared using polyacrylamide gel electrophoresis (PAGE).
As results of this study, in parotid saliva, there was no difference in protein compositions between the rampant dental caries and the caries free children. While electrophoresis was done with the whole saliva, protein with 120 KDa was found in
children
with rampant dental caries. However, this protein was not found or unclear, if any for the caries free group.(Exceptionally, clear protein band was present for one person.) Protein compositions of whole saliva of rampant dental caries group was
compared
before and after the caries control and thick and clear protein bands of about 120 KDa were found in both cases. Protein compostions of caries free children and adults were identical. Quantitative analysis of protein was done for the rampant
dental
caries group and the control group and no significant difference was found.
Taken all together, protein withmolecular weight of 120 KD, found in rampant dental caries group, was still present wen the treatment for the dental caries was done so it can be assumed that this protein has no interrelation with the presence of
active
carious lesions during saliva collecting. It an also be presumed that this specific salivary protein with the molecular weight of 120 KDa found in rampant dental caries group has effect on development and progress of dental caries. Identification
on
this protein with the molecular-weight of 120 KDa an the role of this protein against dental caries remain to be solved.
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